Inflammatory Bowel Disease (IBD) / Crohn's / Ulcerative Colitis
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Inflammatory Bowel Disease (IBD) primarily describe the inflammatory bowel conditions, Crohn's Disease and Ulcerative Colitis. Neither has any effective or reasonable cures with standard treatment, and the best case is prolonged remission. A fair amount of research has been done on hyperbaric oxygen therapy (HBOT) as a treatment for IBD. The typical study participant is an end stage case that is refractory to treatment. Even in these cases, HBOT often has the result of putting the condition into remission in 30 treatments. In our experience, clients respond to the treatment quickly, showing improvement in bowel function and other symptoms almost right away, with progressive improvement with repeated treatment.
Mechanisms of action of HBOT for IBD:
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Scientific Resources Supporting HBOT for IBD
Dr. Dan Rossignol, MD, summarizes the current state of research related to IBD and HBOT. There have been numberous studies assessing the effectiveness of HBOT for IBD, but this summary is by far the best reference to consider.
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- 2024 - Hyperbaric oxygen therapy ameliorates intestinal and systematic inflammation by modulating dysbiosis of the gut microbiota in Crohn's disease
- 2014 - Systematic review: The safety and efficacy of hyperbaric oxygen therapy for inflammatory bowel disease.
- 2014 - Healing under pressure: hyperbaric oxygen and myocutaneous flap repair for extreme persistent perineal sinus after proctectomy for inflammatory bowel disease.
- 2012 - Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis.
Scientific Resources Supporting HBOT for Ulcerative Colitis
- 2018 - Recalcitrant Vulval and Perineal Crohn Disease Responding to Hyperbaric Oxygen Therapy.
- 2016 - Hyperbaric oxygen therapy stimulates colonic stem cells and induces mucosal healing in patients with refractory ulcerative colitis: a prospective case series
- 2015 - Hyperbaric oxygen therapy for chronic antibiotic-refractory ischemic pouchitis.
- 2008 - Hyperbaric oxygen therapy is as effective as dexamethasone in the treatment of TNBS-E-induced experimental colitis.
- 2006 - Hyperbaric oxygen enhances the efficiency of 5-aminosalicylic acid in acetic acid-induced colitis in rats.
- 2004 - Effect of hyperbaric oxygen on experimental acute distal colitis.
- 2001 - Hyperbaric oxygen therapy for severe ulcerative colitis.
Scientific Resources Supporting HBOT for Crohn's Disease
- 2016 - Adjunctive Hyperbaric Oxygen Therapy promotes successful healing in patients with refractory Crohn's disease.
- 2013 - Efficacy of hyperbaric oxygen in patients with Crohn's disease: two case reports.
- 2012 - Hyperbaric oxygen in the treatment of perineal Crohn's disease era of infliximab: a renewal interest?
- 2011 - Crohn's disease and hyperbaric oxygen therapy.
- 1999 - Hyperbaric oxygen therapy for perineal Crohn's disease.
Biofilm Infection
It has been reported by Wolcott et al. that Inflammatory Bowel Disease has a biofilm component. Biofilm is a form that multi-kingdom bacteria can take in the body, that are strongly antibiotic and immune resistant. It is believed that the chronicity of many infections can be attributed to this bacterial form. HBOT has been shown to be a effective potentiator of antibiotics in many biofilm infections, it remains to be seen if HBOT has a direct anti-biofilm effect. For more information visit our biofilm page.
Fungal Component involved in IBD
In 2016, new revelations were found building on the understanding that the gut microflora is affected in IBD. It was previously understood that the bacterial microflora of the gut was affected but now we know that there is a fungal component to this gut dysbiosis.
