Calciphylaxis / Calcific Uremic Arteriolopathy
Calciphylaxis, otherwise known as Calcific Uremic Arteriopathy, often results in problem wounds that don't respond to conventional treatment.
There are many published cases that suggest that wounds caused by Calciphylaxis respond in a similar way as other approved problem wounds when using the standard hyperbaric problem wound treatment protocol. Currently, problem wounds associated with Calciphylaxis are not approved by the Undersea and Hyperbaric Medical Society (UHMS) for reimbursement.
A multidisciplinary approach has the best chances of success. A 2014 calciphylaxis case at our facility experienced full closure of 3 wounds by using 30 treatments at 2.4 ATA for 90 minutes each.
- 2016 Case Series - Patient Outcomes and Factors Associated with Healing in Calciphylaxis Patients Undergoing Adjunctive Hyperbaric Oxygen Therapy. - Full Text
- 2016 Case Series - Survival, Risk Factors, and Effect of Treatment in 101 Patients With Calciphylaxis.
- 2016 Cohort Study - Calciphylaxis in peritoneal dialysis patients: a single center cohort study.
- 2016 Case Study - The Successful Treatment of Calciphylaxis with Sodium Thiosulfate and Hyperbaric Oxygen in a Non-dialyzed Patient with Chronic Kidney Disease.
- 2015 - Calcific uremic arteriolopathy (Calcyphilaxis): a rare disease? Report of three cases
- 2015 - Hyperbaric oxygen in the treatment of calciphylaxis: A case series and literature review.
- 2014 Case Study - Successful treatment of calciphylaxis by a multidisciplinary approach. - Full Text
- 2014 Case Study - Calcific uremic arteriolopathy ameliorated by hyperbaric oxygen therapy in high-altitude area.
- 2012 Australian Cases - Calcific uremic artteriolopathy on multimodal combination therapy: Still unmet goal -Full Text
- 2012 Case Stugy - Maximal conservative therapy of calcific uremic arteriolopathy
- 2011 Article - Calcific uremic arteriolopathy in peritoneal dialysis populations. - Full Text
- 2011 American Cases - Multi-intervention management of calciphylaxis: a report of 7 cases.
- 2010 Article - Calcific uremic arteriolopathy - the argument for hyperbaric oxygen and sodium thiosulfate
- 2010 French Cases - Calciphylaxis in dialysis patients: to recognize and treat it as soon as possible.
- 2010 Case Study - Successful treatment of calcific uremic arteriolopathy in a pediatric dialysis patient.
- 2010 Case Study - Atypical calciphylaxis in a patient receiving warfarin then resolving with cessation and application of hyperbaric oxygen therapy.
- 2009 Case Study - Review of calciphylaxis and treatment of a severe case after kidney transplantation with ilioprost in combination with hyperbaric oxygen and cultured autologous fibrin-bases skin substitutes.
- 2009 Article - Possible application of hyperbaric oxygen technology in the management of urogenital and renal diseases.
- 2008 Article - Management of calcific uremic arteriolopathy (calciphylaxis) with a combination of treatments, including hyperbaric oxygen therapy.
- 2008 Article - Calcific uremic arteriolopathy: and update
- 2008 Australian Case Study - Hyperbaric oxygen therapy in the treatment of skin ulcers due to calcific uraemic arteriolopathy: experience from an Australian hyperbaric unit.
- 2007 Article - Calcific uremic arteriolopathy: advances in pathogenesis and treatment.
- 2003 Article - Vascular calcification in chronic renal failure.
- 2002 Case Study - Calcific uraemic arteriolopathy: local treatment and hyperbaric oxygen therapy. -Full Text
- 2002 Case Series - Hyperbaric oxygen therapy for calcific uremic arteriolopathy: a case series.
- 2001 Case Series - Hyperbaric oxygen int the treatment of calciphylaxis: a case series. - Full Text
- 1998 Case Series - Cutaneous necrosis from calcific uremic arteriolopathy
- 1994 Case Study - Hyperbaric oxygen therapy in calciphylaxis-induced skin necrosis in a peritoneal dialysis patient.
Biofilms in Problem Wounds
It has been reported by Wolcott et al. that problem wounds have a biofilm component. This is the main reason for the regular debridement of wounds in standard wound care. Physical removal of the infected surface of problem wounds is one of the only effective ways to remove the biofilm infection. Biofilm is a multi-kingdom form that bacteria can take in the body, that are strongly antibiotic and immune resistant. It is believed that the chronicity of many infections can be attributed to this bacterial form. HBOT has been shown to be a effective potentiator of antibiotics in many biofilm infections, it remains to be seen if HBOT has a direct anti-biofilm effect. For more information visit our biofilm page.