Read Oceanside Hyperbaric's featured article on The Effects of Hyperbaric Oxygenation on Oxidative Stress, Inflammation and Angiogenesis, with clear, research-informed context and practical takeaways.
This systematic review examined human studies measuring how hyperbaric oxygen therapy affects three closely related biological processes: oxidative stress, inflammation and angiogenesis—the formation and development of blood vessels.
Across the studies reviewed, HBOT produced measurable changes in oxidative signalling while being associated with reductions in several pro-inflammatory proteins, interleukins and cytokines. Researchers also observed increases in growth factors and other signals associated with angiogenesis. Some responses were strongest after the first exposure or occurred transiently after individual treatments, illustrating that the body's response to hyperbaric oxygen is dynamic rather than simply cumulative.
The authors concluded that HBOT can influence inflammatory and vascular signalling in humans, while emphasizing that additional research is needed to determine how these biological changes translate into clinical outcomes in different conditions.
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