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Cerebral Radionecrosis

Cerebral radionecrosis is delayed injury and death of brain tissue after radiation treatment. It can cause swelling and neurological symptoms, and may resemble tumour progression on imaging. Specialist evaluation is essential to distinguish these possibilities and select appropriate treatment.

HBOT has been used for selected patients with confirmed radiation necrosis. A small retrospective series reported improvement in some patients, but results were not consistent and did not extend to all types of delayed central nervous system injury. The evidence is substantially less certain than a large randomized trial would provide.

This condition falls within the broader clinical area of delayed radiation injury. Decisions about HBOT should be made with the neuro-oncology or radiation-oncology team, alongside other treatments for swelling or tissue injury. HBOT does not treat a recurrent brain tumour.

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